Comparative efficacy and acceptability of 12 new-generation antidepressants pdf

This is the newest nma and therefore these results are very important in terms of. Comparative efficacy and tolerability of newgeneration. We expressed these using fluoxetine as reference drug, because it was the first among these 12 antidepressants to be marketed in europe and the usa, and it has been consistently used as reference drug among the different pairwise comparisons. The results will also have implications for clinical practice and further research. Comparative efficacy and acceptability were analyzed. Choosing a second generation antidepressant for treatment. Au cipriani a, furukawa ta, salanti g, geddes jr, higgins jp, churchill r, watanabe n, nakagawa a, omori im, mcguire h, tansella m, barbui c. Comparative efficacy and acceptability of firstgeneration. We report an overview of all randomised controlled trials that compared 12 newgeneration antidepressants in terms of efficacy and acceptability in the acutephase treatment of major depression. Comparative efficacy, acceptability, and tolerability of. Dropout rate was used to represent acceptability, because the authors believed it to be a more clinically meaningful measure than either side effects or symptom scores. We therefore did a multipletreatments metaanalysis, which accounts for both direct and indirect comparisons, to assess the effects of 12 newgeneration antidepressants.

Included studies were randomised controlled trials rcts that compared any of 12 newgeneration antidepressants bupropion, citalopram, duloxetine, escitalopram, fluoxetine, fluvoxamine, milnaciprin, mirtazapine, paroxetine, reboxetine, sertraline, and venlafaxine as monotherapy for acutephase. Comparative efficacy and tolerability of firstgeneration. Comparative effectiveness of secondgeneration antidepressants in the pharmacologic treatment of adult depression. Fluoxetinethe first of the secondgeneration antidepressants was used as. Andrea cipriani department of medicine and public health, section of psychiatry and clinical psychology, university of verona, italy. We will use mtm to estimate the comparative efficacy and acceptability of the twelve most frequently used new generation antidepressants for acute treatment of major depression. We therefore did a multipletreatments metaanalysis, which accounts for both direct and indirect comparisons, to assess the effects of 12 newgeneration antidepressants on major depression. The most recent metaanalysis found little difference in efficacy among second generation antidepressants,3 whereas an earlier one found that escitalopram and sertraline had the best efficacy to acceptability ratio. Comparative efficacy and acceptability of seven augmentation agents for treatmentresistant depression. Comparative efficacy and acceptability of amitriptyline. Although there has been a lot of public debate about the role of antidepressants, a robust metaanalysis by cipriani et al 1 has demonstrated that antidepressants are more effective than placebo in the treatment of major depressive disorder. Comparative efficacy and acceptability of psychotherapies. Selective publication of antidepressant trials and its influence on apparent efficacy. Depressive disorders in children and adolescents are a major public health problem.

Reboxetine, sold under the brand name edronax among others, is a drug of the norepinephrine reuptake inhibitor nri class, marketed as an antidepressant by pfizer for use in the treatment of major depression, although it has also been used offlabel for panic disorder and attention deficit hyperactivity disorder adhd. Differences in efficacy and acceptability exist for 12 newgeneration antidepressants for major depression, year. Cipriani a1, furukawa ta, salanti g, geddes jr, higgins jp, churchill r, watanabe n, nakagawa a, omori im, mcguire h, tansella m, barbui c. Data were analyzed for comparative efficacy among antidepressants and for adverse effects. Assessing and enhancing the effectiveness of antidepressants. In their view, methodological shortcomings limit the validity of our results and the conclusions reached. Comparative efficacy and acceptability of 12 newgeneration. Comparative efficacy and tolerability of newgeneration antidepressants for major depressive disorder in children and adolescents.

Finally, we looked at comparative efficacy among the 12 antidepressant drugs. Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder. Reproduced from cipriani a, furukawa ta, salanti g, et al 2009. Comparative efficacy and acceptability of newgeneration antidepressants. In addition, indirect comparisons were made between trials by combining results of efficacy when compared with a common comparator treatment. When starting an antidepressant, try either of these 2. Comparative efficacy and acceptability of pharmacological. Comparative efficacy and acceptability of firstgeneration and secondgeneration antidepressants in the acute treatment of major depression. Full text comparative efficacy, acceptability, and. Comparative efficacy and acceptability of psychotherapies for depression in children and adolescents. Pdf comparative efficacy and acceptability of 12 new.

Newgeneration antidepressant drugs, including serotonin selective reuptake inhibitors and serotonin norepinephrine reuptake inhibitors, have gained wide acceptance. In major depressive disorder, antidepressant drugs. How they stack up researchers rank 12 common antidepressants on efficacy, acceptability. Comparative efficacy and tolerability of antidepressants. A large metaanalysis found these medications to be superior to other newgeneration antidepressants. Guide to antidepressant medications truth in drugs. Comparative efficacy and acceptability of amitriptyline, duloxetine and milnacipran in fibromyalgia syndrome. Conventional metaanalyses have shown inconsistent results for efficacy of secondgeneration antidepressants. Previous pairwise metaanalyses were done to evaluate the efficacy of all types of antidepressants8. Health, general antidepressants comparative analysis patient outcomes antidepressants, tricyclic health aspects antipsychotic agents antipsychotic drugs behavior therapy. We report an overview of all randomised controlled trials that compared 12 newgeneration antidepressants in terms of efficacy and acceptability in the. Citeseerx comparative efficacy and acceptability of 12. Comparative efficacy and acceptability of 12 newgeneration antidepressants.